Last update :
19/11/2024
References   References 1411  
Type : Journal PC : 0.0006830601092896 

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Trissel LA.
Title : Physical and chemical stability of etoposide phosphate solutions.
Reference : J Am Pharm Assoc ; 39: 146-150. 1999

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionEtoposide phosphate Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 & 10 mg/ml 23°C Not specified
31 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 & 10 mg/ml 32°C Not specified
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 & 10 mg/ml 4°C Protect from light
31 Day
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 10 & 20 mg/ml 23°C Not specified
31 Day
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 10 & 20 mg/ml 32°C Not specified
7 Day
Stability in solutions Polypropylen Syringe Water for injection + antibacterial 10 & 20 mg/ml 4°C Protect from light
31 Day

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