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References   References 12  
Type : Journal
Research teams : Winston-Salem - Wake Forest School of Medicine
Authors : Owens LC, Fleming RA, Restino MS, Cruz JM, Hurd DD.
Title : Stability of amphotericin B 0.05 and 0.5 mg/ml in 20% fat emulsion.
Reference : Am J Health-Syst Pharm ; 54: 683-686. 1997
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions
List of drugs
InjectionAmphotericin B Antifungal
Stability in solutions Polyvinyl chloride Glucose 5% 0,05 & 0,5 mg/ml 23°C-25°C With or without light
24 Hour
  Mentions Légales