Last update :
08/05/2024
References   References 1197  
Type : Journal

Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Deans KW, Lang JR, Smith DE.
Title : Stability of trimethoprim-sulfamethoxazole injection in five infusion fluids.
Reference : Am J Hosp Pharm ; 39: 1681-1684. 1982

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionCo-trimoxazole Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 0,6/3,2 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 1,6/8 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 0,6/3,2 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 1,6/8 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Ringer’s lactate solution 0,6/3,2 mg/ml 23-25°C Not specified
12 Hour
Stability in solutions Glass Ringer’s lactate solution 1,6/8 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,45% 0,6/3,2 mg/ml 23-25°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,45% 1,6/8 mg/ml 23-25°C Not specified
24 Hour

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