Last update :
19/11/2024
References   References 1178  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Benvenuto JA, Anderson RW, Kerkof K, Smith RG, Loo TL.
Title : Stability and compatibility of antitumor agents in glass and plastic containers.
Reference : Am J Hosp Pharm ; 38: 1914-1918. 1981

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Method not shown but used to deposit authorization to market
No comments for the degradation products

List of drugs
injectionDactinomycin Anticancer drug
Stability in solutions Glass Glucose 5% 9.8 µg/ml 25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 9.8 µg/ml 25°C Protect from light
24 Hour
injectionMitomycin Anticancer drug
Factors which affect stability Solvent Glucose 5% Induces Degradation
Incompatible + Glucose 5%

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