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References   References 11  
Type : Journal
Research teams : Piscataway - State University of New Jersey, College of Pharmacy
Authors : Bailey LC, Orosz ST.
Title : Stability of ceftriaxone sodium and metronidazole hydrochloride.
Reference : Am J Health-Syst Pharm ; 54: 424-427. 1997
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionCeftriaxone disodium Antibiotic
Incompatible 20 mg/ml + injectionMetronidazole 15 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 mg/ml + injectionMetronidazole 7.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMetronidazole Antiparasitic
Incompatible 15 mg/ml + injectionCeftriaxone disodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 7.5 mg/ml + injectionCeftriaxone disodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 24-26°C Not specified
injection Ceftriaxone disodium 10 mg/ml
injection Metronidazole 7,5 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4-6°C Protect from light
injection Ceftriaxone disodium 10 mg/ml
injection Metronidazole 7,5 mg/ml
72 Hour
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