Last update :
19/11/2024
References   References 1049  
Type : Journal

Research teams : Omaha - University of Nebraska Medical center, College of pharmacy
Authors : Klamerus KJ, Ueda CT, Newton DW.
Title : Stability of nitroglycerin in intravenous admixtures.
Reference : Am J Hosp Pharm ; 41: 303-305. 1984

Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No visual inspection
Method not shown but the article refers to a validated method

List of drugs
injectionAminophylline Various
Compatible 1 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionBretylium tosilate Anti-arrhythmic
Compatible 10 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionFurosemide Diuretic
Compatible 0.67 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionHydralazine hydrochloride Antihypertensive
Incompatible 1 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + injectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.4 mg/ml + injectionBretylium tosilate 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.4 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.4 mg/ml + injectionFurosemide 0.67 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.4 mg/ml + injectionHydralazine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.4 mg/ml + injectionLidocaine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.4 mg/ml + injectionPhenytoin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhenytoin sodium Antiepileptic
Incompatible 1 mg/ml + injectionNitroglycerin 0.4 mg/ml + NaCl 0,9% or Glucose 5%

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