Last update :
29/10/2024
References   References 1028  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Cheung YW, Vishnuvajjala BR, Flora KP.
Title : Stability of cytarabine, methotrexate sodium, and hydrocortisone sodium succinate admixtures.
Reference : Am J Hosp Pharm ; 41: 1802-1806. 1984

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
injectionCytarabine Anticancer drug
injectionHydrocortisone sodium succinate Anti-inflammatory
injectionMethotrexate sodium Anticancer drug
Stability of mixtures
Polypropylen Syringe NaCl 0,9% or Glucose 5% 25°C Not specified
injection Hydrocortisone sodium succinate 2 mg/ml
injection Methotrexate sodium 1 mg/ml
injection Cytarabine 4,1 mg/ml
24 Hour
Polypropylen Syringe Ringer’s lactate solution 25°C Not specified
injection Hydrocortisone sodium succinate 2 mg/ml
injection Methotrexate sodium 1 mg/ml
injection Cytarabine 4,1 mg/ml
24 Hour
Polypropylen Syringe Elliott’s B solution 25°C Not specified
injection Hydrocortisone sodium succinate 2 mg/ml
injection Methotrexate sodium 1 mg/ml
injection Cytarabine 4,1 mg/ml
24 Hour

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