Last update :
18/07/2024
References   References 934  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=452

Research teams : Nagoya - Meijo University, Faculty of Pharmacy
Authors : Inagaki K, Kambara M, Mizuno M, Okuda J, Gill MA, Nishida M.
Title : Compatibility and stability of ranitidine hydrochloride with six cephalosporins during simulated Y-site administration.
Reference : Int J Pharm Compound ; 2: 318-321. 1998

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionCefmenoxime Antibiotic
Compatible 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCefoperazone sodium Antibiotic
Compatible 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionCefuzonam Antibiotic
Compatible 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionMoxalactam Antibiotic
Compatible 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + injectionCefmenoxime 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCefoperazone sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCeftizoxime sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionCefuzonam 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMoxalactam 20 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Moxalactam 10 mg/ml
2 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Ceftizoxime sodium 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Cefoperazone sodium 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Cefmenoxime 10 mg/ml
4 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Ranitidine hydrochloride 0,5 mg/ml
injection Cefuzonam 10 mg/ml
4 Hour

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