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References   References 903  
Type : Journal
Web link : https://journal.pda.org/content/47/1/35
Research teams : Los Angeles - University of Southern california, School of Pharmacy
Authors : Inagaki K, Gill MA, Okamoto MP, Takagi J.
Title : Chemical compatibility of cefmetazole sodium with ranitidine hydrochloride during simulated Y-site administration.
Reference : J Parenter Sci Technol ; 47: 35-39. 1993
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionCefmetazole sodium Antibiotic
Incompatible 10 & 20 mg/ml + injectionRanitidine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Incompatible 1 mg/ml + injectionCefmetazole sodium 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 22°C-23°C Light
injection Ranitidine hydrochloride 1 mg/ml
injection Cefmetazole sodium 20 mg/ml
2 Hour
Glass Sodium chloride 0,9% 22°C-23°C Light
injection Cefmetazole sodium 10 mg/ml
injection Ranitidine hydrochloride 1 mg/ml
4 Hour
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