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References   References 872  
Type : Journal
Web link : https://doi.org/10.1177/106002809703101204
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang YP, Xu QA, Trissel LA, Gilbert DL, Martinez F.
Title : Compatibility and stability of paclitaxel combined with cisplatin and with carboplatin in infusion solutions.
Reference : Ann Pharmacotherapy ; 31: 1465-1470. 1997
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products
List of drugs
injectionCarboplatin Anticancer drug
Compatible 2 mg/ml + injectionPaclitaxel 0,3 & 1,2 mg/ml + NaCl 0,9% or Glucose 5%
injectionCisplatin Anticancer drug
Compatible 0,2 mg/ml + injectionPaclitaxel 0,3 & 1,2 mg/ml + Sodium chloride 0,9%
injectionPaclitaxel Anticancer drug
Compatible 0,3 & 1,2 mg/ml + injectionCarboplatin 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0,3 & 1,2 mg/ml + injectionCisplatin 0,2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyolefine NaCl 0,9% or Glucose 5% 23°C Not specified
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Carboplatin 2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 32°C Not specified
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Carboplatin 2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Paclitaxel 0,3 & 1,2 mg/ml
injection Carboplatin 2 mg/ml
24 Hour
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