Last update :
19/11/2024
References   References 844  
Type : Journal

Research teams : Poitiers - Université de Poitiers, Faculté de Médecine et Pharmacie
Authors : Rochard E, Chapelle G, Bouquet S, Barthes D, Courtois PH.
Title : Stability of fluorouracil and cytarabine in ethylvinylacetate containers.
Reference : J Pharm Clin ; 9: 31-35. 1989

Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A Fluorouracil
Level of evidence B Cytarabine
Physical stability : 
Chemical stability : 
Thin Layer ChromatographyFluorouracil
Stability defined as 95% of the initial concentrationFluorouracil
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Fluorouracil
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Cytarabine
Stability defined as 90% of the initial concentrationCytarabine
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
Degradation products identified and quantifiedFluorouracil

List of drugs
injectionCytarabine Anticancer drug
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 25°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 35°C Protect from light
14 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 1,25 & 25 mg/ml 4°C Protect from light
28 Day
injectionFluorouracil Anticancer drug
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 35°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate NaCl 0,9% or Glucose 5% 10 mg/ml 4°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate None 50 mg/ml 25°C Protect from light
28 Day
Stability in solutions Ethylene vinyl acetate None 50 mg/ml 35°C Protect from light
28 Day

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