Last update :
14/12/2024
References   References 686  
Type : Journal

Research teams : Birmingham - Aston University, Pharmaceutical Sciences Institute
Authors : Wood MJ, Irwin WJ, Scott DK.
Title : Stability of doxorubicin, daunorubicin and epirubicin in plastic syringes and minibags.
Reference : J Clin Pharm Ther ; 15: 279-289. 1990

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products not observed in real conditions

List of drugs
injectionDaunorubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml -20°C Protect from light
43 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 25°C Not specified
43 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
43 Day
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 4°C Protect from light
43 Day
injectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml -20°C Protect from light
43 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 25°C Not specified
24 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
43 Day
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 4°C Protect from light
43 Day
injectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml -20°C Protect from light
43 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 25°C Not specified
20 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,1 mg/ml 4°C Protect from light
43 Day
Stability in solutions Polypropylen Syringe Water for Injection 2 mg/ml 4°C Protect from light
43 Day

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