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References   References 592  
Type : Journal
Research teams : Poitiers - Université de Poitiers, Faculté de Médecine et Pharmacie
Authors : Barthes D, Fauconneau B, Martin JP, Courtois P.
Title : Effects of storage temperature and pH on the stability of cefotaxime in PVC bags.
Reference : J Pharm Clin ; 8: 101-106. 1989
Level of Evidence : 
Level of evidence C
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
No visual inspection
List of drugs
injectionCefotaxime sodium Antibiotic
Factors which affect stability pH 4,5 < pH < 5,5 Induces Enhanced stability
Stability in solutions Polyvinyl chloride Glucose 5% 10 mg/ml -20°C Protect from light
90 Day
Stability in solutions Polyvinyl chloride Glucose 5% 10 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 10 mg/ml 4°C Protect from light
4 Day
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