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References   References 539  
Type : Journal
Research teams : Boston - New England Deaconess Hospital
Authors : Baptista RJ, Mitrano FP.
Title : Stability and compatibility of cimetidine hydrochloride and aminophylline in dextrose 5% in water injection.
Reference : Drug Intell Clin Pharm ; 22: 592-593. 1988
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method
List of drugs
injectionAminophylline Various
Stability in solutions Polyvinyl chloride Glucose 5% 0,5 mg/ml 25°C Protect from light
48 Hour
Compatible 0,5 mg/ml + injectionCimetidine hydrochloride 1,2 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Stability in solutions Polyvinyl chloride Glucose 5% 1,2 mg/ml 25°C Protect from light
48 Hour
Compatible 1,2 mg/ml + injectionAminophylline 0,5 mg/ml + Glucose 5%
Stability of mixtures
Polyvinyl chloride Glucose 5% 25°C Protect from light
injection Cimetidine hydrochloride 1,2 mg/ml
injection Aminophylline 0,5 mg/ml
48 Hour
  Mentions Légales