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References   References 512  
Type : Journal
Web link : http://springerlink.metapress.com/content/kk73ql561q144256/?p=703db277eb86488e9d73aa37c735886f&pi=4
Research teams : Birmingham - Aston University, Pharmaceutical Sciences Institute
Authors : Barnes AR, Nash S.
Title : Stability of bupivacaine hydrochloride with diamorphine hydrochloride in an epidural infusion.
Reference : Pharm World Sci ; 17: 87-92. 1995
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Water loss by evaporation 
Comments : 
List of drugs
injectionBupivacaine hydrochloride Local anesthetic
Compatible 1.5 mg/ml + injectionDiamorphine hydrochloride 0.02 mg/ml + Sodium chloride 0,9%
injectionDiamorphine hydrochloride Analgesic
Compatible 0.02 mg/ml + injectionBupivacaine hydrochloride 1.5 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% -18C Protect from light
injection Bupivacaine hydrochloride 1,5 mg/ml
injection Diamorphine hydrochloride 0,02 mg/ml
180 Day
Polyvinyl chloride Sodium chloride 0,9% 25°C Light
injection Bupivacaine hydrochloride 1,5 mg/ml
injection Diamorphine hydrochloride 0,02 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% 7°C Protect from light
injection Bupivacaine hydrochloride 1,5 mg/ml
injection Diamorphine hydrochloride 0,02 mg/ml
14 Day
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