Last update :
08/11/2024
References   References 4218  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2018-001515

Research teams : Nottingham - Nottingham City Hospital, Quality Control Laboratory
Authors : Allwood M.C,Stonkute D, Wallace A, Wilkinson A-S, Hills T, Jamieson C,
Title : Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices: INfusor LV (Baxter) and Accufuser (Woo Young Medical): a study compliant with the NHS Yellow Cover Document (YCD) requirements.
Reference : EJHP ; 27, 2: 90-94. 2020

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionFlucloxacillin sodium Antibiotic
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 10 & 50 mg/ml 2-8°C Not specified
13 Day
Stability in solutions Polyisoprene elastomer NaCl 0.9% citrate buffer 0.3% pH7 10 & 50 mg/ml 32°C Not specified
24 Hour
Stability in solutions Silicone elastomer NaCl 0.9% citrate buffer 0.3% pH7 10 & 50 mg/ml 2-8°C Not specified
13 Day
Stability in solutions Silicone elastomer NaCl 0.9% citrate buffer 0.3% pH7 10 & 50 mg/ml 32°C Not specified
24 Hour

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