Last update :
08/11/2024
References   References 4189  
Type : Journal
Web link : https://doi.org/10.1093/ajhp/zxac055

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Kawedia J, Ramchandran S, Liu X, Gulbis A, Titus M, Bashir Q, Qazilbash M, Champlin R, Ciur S,
Title : Stability of Captisol-enabled versus propylene glycol–based melphalan at room temperature and after refrigeration.
Reference : Am J Health-Syst Pharm ;79,12: 1011-1018 2022

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionMelphalan Anticancer drug
Factors which affect stability Temperature 4°C5 mg / ml Induces Precipitation
Stability in solutions Glass specific solvent 5 mg/ml 23°C Not specified
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 23°C Not specified
1 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 4°C Not specified
2 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1,5 & 2 mg/ml 23°C Not specified
2 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1,5 & 2 mg/ml 4°C Not specified
2 Hour
injectionMelphalan captisol Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 23°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 4°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 23°C Not specified
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 4°C Not specified
8 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 23°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2 mg/ml 4°C Not specified
24 Hour

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