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References   References 417  
Type : Journal
Research teams : Memphis - University of Tennessee, College of Pharmacy
Authors : Stewart CF, Hampton EM.
Title : Stability of cisplatin and etoposide in intravenous admixtures.
Reference : Am J Hosp Pharm ; 46: 1400-1404. 1989
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products
List of drugs
injectionCisplatin Anticancer drug
Compatible 0,2 mg/ml + injectionEtoposide 0,2 & 0,4 mg/ml + Sodium chloride 0,9%
Compatible 0,2 mg/ml + injectionEtoposide 0,2 & 0,4 mg/ml + NaCl 0,45% Glucose 5%
injectionEtoposide Anticancer drug
Compatible 0,2 & 0,4 mg/ml + injectionCisplatin 0,2 mg/ml + Sodium chloride 0,9%
Compatible 0,2 & 0,4 mg/ml + injectionCisplatin 0,2 mg/ml + NaCl 0,45% Glucose 5%
Stability of mixtures
Glass Sodium chloride 0,9% 20,5°C-24°C Protect from light
injection Etoposide 0,2 & 0,4 mg/ml
injection Cisplatin 0,2 mg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% 20,5°C-24°C Protect from light
injection Etoposide 0,2 & 0,4 mg/ml
injection Cisplatin 0,2 mg/ml
48 Hour
  Mentions Légales