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References   References 4163  
Type : Journal
Web link : https://ijpc.com/Abstracts/Abstract.cfm?ABS=4524
Research teams : Bâle - F.Hoffman La Roche Ltd
Authors : Nalenz H, K?pf E, Dietel E.
Title : Prolonged In-Use Stability of Reconstituted Herceptin in Commercial Intravenous Bags.
Reference : Int J Pharm Compound 22;5:417-423 2018
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Protein: Size Exclusion Chromatography 
Chemical stability : 
Protein: ionic chromatography
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
injectionTrastuzumab Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,24 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,24 mg/ml 30°C Light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 3,84 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 3,84 mg/ml 30°C Light
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 0,24 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,24 mg/ml 30°C Light
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 3,84 mg/ml 2-8°C Protect from light
7 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 3,84 mg/ml 30°C Light
24 Hour
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