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References   References 412  
Type : Journal PC : 0.0006830601092896 
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Waugh WN, Trissel LA, Stella VJ.
Title : Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers.
Reference : Am J Hosp Pharm ; 48: 1520-1524. 1991
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Search of DEHP 
Comments : 
No comments for the degradation products
List of drugs
injectionPaclitaxel Anticancer drug
Factors which affect stability Container Polyvinyl chloride Induces Leaching
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,6 mg/ml 20°C-23°C Not specified
25 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 1,2 mg/ml 20°C-23°C Not specified
25 Hour
Stability in solutions Polyolefine Glucose 5% 1,2 mg/ml 20°C-23°C Not specified
12 Hour
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