Last update :
19/11/2024
References   References 4056  
Type : Journal
Web link : https://doi.org/10.3747/pdi.2017.00115

Research teams : Hobart - University of Tasmania, School of Pharmacy
Authors : Kandel S, Zaidi S, Wanandy T, Ming L, Castelino R, Sud K, Patel R.
Title : Stability of ceftazidime and heparine in four different types of peritoneal dialysis solutions.
Reference : Perit Dial Int 2017

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method
No comments for the degradation products

List of drugs
injectionCeftazidime Antibiotic
Compatible 0.125 mg/ml + injectionHeparin sodium 0.5 UI/ml + Dianéal® PD2 4.25% glucose (Baxter)
Compatible 0.125 mg/ml + injectionHeparin sodium 0.5 UI/ml + Dianéal® PD2 2.5% glucose (Baxter)
Compatible 0.125 mg/ml + injectionHeparin sodium 0.5 UI/ml + Extraneal® (Baxter)
injectionHeparin sodium Anticoagulant
Compatible 0.5 UI/ml + injectionCeftazidime 0.125 mg/ml + Dianéal® PD2 4.25% glucose (Baxter)
Compatible 0.5 UI/ml + injectionCeftazidime 0.125 mg/ml + Dianéal® PD2 2.5% glucose (Baxter)
Compatible 0.5 UI/ml + injectionCeftazidime 0.125 mg/ml + Extraneal® (Baxter)
Stability of mixtures
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 37°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
12 Hour
Polyvinyl chloride Dianéal® PD2 4.25% glucose (Baxter) 4°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
120 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 37°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
12 Hour
Polyvinyl chloride Dianéal® PD2 2.5% glucose (Baxter) 4°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
120 Hour
Polyvinyl chloride Extraneal® (Baxter) 37°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
12 Hour
Polyvinyl chloride Extraneal® (Baxter) 4°C Not specified
injection Ceftazidime 0.125 mg/ml
injection Heparin sodium 0.5 UI/ml
120 Hour

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