Last update :
08/11/2024
References   References 4049  
Type : Journal
Web link : http://doi.org/10.1016/j.jpba.2017.12.012

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Tokhadze N, Chennell P, Le Basle Y, Sautou V.
Title : Stability of infliximab solutions in different temperature and dilution conditions.
Reference : J Pharm Biomed Anal ; 150 : 386-395 2018

Level of Evidence : 
Level of evidence B+
Physical stability : 
Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: Peptide mapping
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Protein: intrared spectrometry and second derivative
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
injectionInfliximab Immunosuppressant
Stability in solutions Glass Water for Injection 10 mg/ml 25°C Protect from light
7 Day
Biosimilar
Stability in solutions Glass Water for Injection 10 mg/ml 5°C Protect from light
14 Day
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 0.4 mg/ml 25°C Protect from light
30 Day
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 0.4 mg/ml 5°C Protect from light
90 Day
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 2 mg/ml 25°C Protect from light
30 Day
Biosimilar
Stability in solutions Polyolefine Sodium chloride 0,9% 2 mg/ml 5°C Protect from light
90 Day
Biosimilar

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