Last update :
19/11/2024
References   References 3951  
Type : Journal
Web link : http://onlinelibrary.wiley.com/doi/10.1111/j.1542-4758.2009.00368.x/full

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Battistella M, Walker S, law S, Lok C.
Title : Antibiotic lock: In vitro stability of vancomycin and four percent sodium citrate stored in dialysis catheters at 37°C
Reference : Hemodial Int ; 13, 3: 322-328. 2009

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionSodium citrate Electrolyte
Compatible 40 mg/ml + injectionVancomycin hydrochloride 1 & 3 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Compatible 1 & 3 mg/ml + injectionSodium citrate 40 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 23°C Light
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 23°C Light
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 3 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 3 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
72 Hour
Not specified Sodium chloride 0,9% 37°C Light
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
72 Hour
Not specified Sodium chloride 0,9% 37°C Light
injection Sodium citrate 40 mg/ml
injection Vancomycin hydrochloride 3 mg/ml
72 Hour

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