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References   References 3927  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4275
Research teams : Waltham - TESARO Inc, Waltham
Authors : Wu G,Yeung S,Chen F.
Title : Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Dexamethasone Sodium Phosphate.
Reference : Int J Pharm Compound ; 21, 1 : 66-75. 2017
Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.09 & 0.18 mg/ml + injectionRolapitant 1.7 mg/ml + None
injectionRolapitant Antiemetic
Compatible 1.7 mg/ml + injectionDexamethasone sodium phosphate 0.09 & 0.18 mg/ml + None
Stability of mixtures
Glass None 20-25°C Light
injection Rolapitant 1,7 mg/ml
injection Dexamethasone sodium phosphate 0,086 mg/ml
6 Hour
Glass None 20-25°C Light
injection Rolapitant 1,7 mg/ml
injection Dexamethasone sodium phosphate 0,170 mg/ml
6 Hour
Cristal Zenith® None 20-25°C Light
injection Rolapitant 1,7 mg/ml
injection Dexamethasone sodium phosphate 0,170 mg/ml
6 Hour
Cristal Zenith® None 20-25°C Light
injection Rolapitant 1,7 mg/ml
injection Dexamethasone sodium phosphate 0,086 mg/ml
6 Hour
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