Last update :
19/11/2024
References   References 3897  
Type : Journal
Web link : http://www.degruyter.com/view/j/pthp.ahead-of-print/pthp-2016-0012/pthp-2016-0012.xml?format=INT

Research teams : Angers - University Hospital of Angers, Pharmacy Department
Authors : Briot T, Truffaut C, Le Quay L, Lebreton A, Lagarce F.
Title : Stability of Reconstituted and Diluted Mitomycin C Solutions in Polypropylene Syringes and Glass Vials.
Reference : Pharmaceutical Technology in Hospital Pharmacy ;1,2:83-89 2016

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products detected but not quantified

List of drugs
injectionMitomycin Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 25°C Protect from light
8 Hour
conflicting data
Stability in solutions Polypropylen Syringe Water for Injection 1 mg/ml 25°C Protect from light
8 Hour
conflicting data
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 25°C Protect from light
10 Hour
conflicting data

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