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References   References 3865  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4145
Research teams : Springfield - Western New England University College of Pharmacy
Authors : Vicky M, Samit S, Jaymin P, Michael C T.
Title : Compatibility of Norepinephrine Bitartrate with Levofloxacin and Moxifloxacin During Simulated Y-site Administration.
Reference : Int J Pharm Compound ; 20, 3 : 236-238. 2016
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionLevofloxacine Antibiotic
Compatible 5 mg/ml + injectionNorepinephrine bitartrate 0,064 mg/ml + Glucose 5%
injectionMoxifloxacin Antibiotic
Compatible 1,6 mg/ml + injectionNorepinephrine bitartrate 0,064 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,064 mg/ml + injectionLevofloxacine 5 mg/ml + Glucose 5%
Compatible 0,064 mg/ml + injectionMoxifloxacin 1,6 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C
injection Norepinephrine bitartrate 0,032 mg/ml
injection Levofloxacine 2,5 mg/ml
4 Hour
Glass Glucose 5% 25°C
injection Norepinephrine bitartrate 0,032 mg/ml
injection Moxifloxacin 0,8 mg/ml
4 Hour
  Mentions Légales