Last update :
08/11/2024
References   References 3847  
Type : Journal
Web link : http://www.tandfonline.com/doi/pdf/10.3109/15360288.2015.1098762

Research teams : Rochester - Wegmans School of Pharmacy
Authors : Raphael C.D, Zhao F, Hughes S.E, Juba K.M.
Title : A Pilot Chemical and Physical Stability Study of Extemporaneously Compounded Levetiracetam Intravenous Solution.
Reference : J Pain Palliat Care Pharm ; 29, 4: 370-373. 2016

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionLevetiracetam Antiepileptic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 40 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 40 mg/ml 2-8°C Not specified
14 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 40 mg/ml 2-8°C Not specified
14 Day

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