Last update :
08/11/2024
References   References 3694  
Type : Journal

Research teams : New York - Memorial Sloan-Kettering Cancer Center
Authors : Smith J.A, Morris A, Duafala M.E, Bertino J.R, Markman M, Kleinberg M.
Title : Stability of floxuridine and leucovorin calcium admixtures for intraperitoneal administration.
Reference : Am J Hosp Pharm ; 46: 985-989. 1989

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionFloxuridine Anticancer drug
Compatible 1 >> 4 mg/ml + injectionFolinate calcium 0.03 >> 0.960 mg/ml + Sodium chloride 0,9%
injectionFolinate calcium Cytoprotective
Compatible 0.03 >> 0.960 mg/ml + injectionFloxuridine 1 >> 4 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified Sodium chloride 0,9% 20°C Protect from light
injection Floxuridine 1 mg/ml
injection Folinate calcium 0.03 mg/ml
48 Hour
Not specified Sodium chloride 0,9% 20°C Protect from light
injection Floxuridine 4 mg/ml
injection Folinate calcium 0.96 mg/ml
48 Hour
Not specified Sodium chloride 0,9% 4-8°C Protect from light
injection Floxuridine 1 mg/ml
injection Folinate calcium 0.03 mg/ml
48 Hour
Not specified Sodium chloride 0,9% 4-8°C Protect from light
injection Floxuridine 4 mg/ml
injection Folinate calcium 0.96 mg/ml
48 Hour
Not specified Sodium chloride 0,9% 40°C Protect from light
injection Floxuridine 1 mg/ml
injection Folinate calcium 0.03 mg/ml
48 Hour
Not specified Sodium chloride 0,9% 40°C Protect from light
injection Floxuridine 4 mg/ml
injection Folinate calcium 0.96 mg/ml
48 Hour

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