Last update :
27/11/2024
References   References 3648  
Type : Journal
Web link : http://www.ajhp.org/content/71/8/669.abstract

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Hossain M.A, Friciu M, Aubin S, Leclair G.
Title : Stability of penicillin G sodium diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in polyvinyl chloride bag containers and elastomeric pump containers.
Reference : Am J Health-Syst Pharm ; 71:669-673. 2014

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
injectionPenicillin G sodium Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.0025 MUI/ml 5°C Not specified
21 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.05 MUI/ml 5°C Not specified
21 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0.0025 MUI/ml 5°C Not specified
21 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0.05 MUI/ml 5°C Not specified
21 Day

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