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References   References 3611  
Type : Journal
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang, Y.-P, Myers, A.L., Trinh, V.A, Kawedia, J.D, Kramer, M.A, Benjamin, R.S, Tran, H.T.
Title : Physical and chemical stability of reconstituted and diluted dexrazoxane infusion solutions.
Reference : J Oncol Pharm Practice ; 20, 1: 58-64. 2014
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Particle counting Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
List of drugs
injectionDexrazoxane hydrochloride Cytoprotective
Stability in solutions Glass Water for Injection 10 mg/ml 25°C Light
8 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 3 mg/ml 25°C Light
8 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 1 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 3 mg/ml 25°C Light
8 Hour
  Mentions Légales