Last update :
16/12/2025
References   References 3476  
Type : Journal
Web link : https://doi.org/10.2146/ajhp130330

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Li M, Coursol C, Leclair G.
Title : Stability of cyclosporine diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in ethylene-vinyl acetate containers.
Reference : Am J Health-Syst Pharm ;70:1970-1972. 2013

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Degradation products not observed in real conditions
Method not shown but used to deposit authorization to market

List of drugs
injectionCiclosporin Immunosuppressant
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 0,2 mg/ml 25°C Not specified
7 Day
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 2,5 mg/ml 25°C Not specified
14 Day
Stability in solutions Ethylene vinyl acetate Glucose 5% 0,2 mg/ml 25°C Not specified
7 Day
Stability in solutions Ethylene vinyl acetate Glucose 5% 2,5 mg/ml 25°C Not specified
14 Day

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