Last update :
19/11/2024
References   References 3470  
Type : Journal
Web link : http://link.springer.com/article/10.1007/s00520-011-1363-x

Research teams : Trente - Azienda Provinciale Servizi Sanitari
Authors : Destro M, Ottolini L, Vicentini L, Boschetti S.
Title : Physical compatibility of binary and tertiary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care.
Reference : Support Care Cancer ; 20: 2501-2509. 2012

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionDiclofenac Anti-inflammatory
Incompatible + injectionMethadone hydrochloride + Sodium chloride 0,9%
Incompatible + injectionMorphine hydrochloride + Sodium chloride 0,9%
injectionKetorolac tromethamine Anti-inflammatory
Compatible 1.76 >> 5.29 mg/ml + injectionMethadone hydrochloride 0.59 >> 2.94 mg/ml + Sodium chloride 0,9%
Compatible 1.76 & 3.53 mg/ml + injectionMorphine hydrochloride 1.18 >> 3.53 mg/ml + Sodium chloride 0,9%
Compatible 1.76 mg/ml + injectionMorphine hydrochloride 4.7 mg/ml + Sodium chloride 0,9%
injectionMethadone hydrochloride Analgesic
Incompatible + injectionDiclofenac + Sodium chloride 0,9%
Compatible 0.59 >> 2.94 mg/ml + injectionKetorolac tromethamine 1.76 >> 5.29 mg/ml + Sodium chloride 0,9%
injectionMorphine hydrochloride Analgesic
Incompatible + injectionDiclofenac + Sodium chloride 0,9%
Compatible 1.18 >> 3.53 mg/ml + injectionKetorolac tromethamine 1.76 & 3.53 mg/ml + Sodium chloride 0,9%
Compatible 4.7 mg/ml + injectionKetorolac tromethamine 1.76 mg/ml + Sodium chloride 0,9%

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