Last update :
19/11/2024
References   References 346  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/0885392494901899

Research teams : Lexington - University of Kentucky, College of Dentistry
Authors : Wulf H, Gleim M, Mignat C.
Title : The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes.
Reference : J Pain Symptom Manage ; 9: 308-311. 1994

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Increased concentration unexplained

List of drugs
injectionBupivacaine hydrochloride Local anesthetic
injectionClonidine hydrochloride Antihypertensive
injectionMorphine hydrochloride Analgesic
Stability of mixtures
Polyvinyl chloride Not specified 25°C Not specified
injection Morphine hydrochloride 6,66 mg/ml
injection Bupivacaine hydrochloride 3 mg/ml
injection Clonidine hydrochloride 0,03 mg/ml
90 Day

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