Last update :
14/12/2024
References   References 3459  
Type : Journal
Web link : http://link.springer.com/article/10.1007/s00280-013-2201-2

Research teams : Whitehouse - Merck manufacturing Division
Authors : Sun S, Schaller J, Placek J, Duersch B.
Title : Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids.
Reference : Cancer Chemother Pharmacol ; 72: 509-513. 2013

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
The method is not specified (poster, letter to the editor)
Degradation products quantified but not identified

List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0,1 mg/ml + injectionFosaprepitant dimeglumine 1 mg/ml + Sodium chloride 0,9%
injectionFosaprepitant dimeglumine Antiemetic
Stability in solutions Not specified NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Light
24 Hour
Compatible 1 mg/ml + injectionDexamethasone sodium phosphate 0,1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionGranisetron hydrochloride 0,026 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMethylprednisolone sodium succinate 0,7 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionOndansetron hydrochloride 0,07 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + injectionPalonosetron hydrochloride 2 µg/ml
Incompatible 1 mg/ml + injectionTropisetron hydrochloride 0,043 mg/ml + Sodium chloride 0,9%
injectionGranisetron hydrochloride Antiemetic
Compatible 0,026 mg/ml + injectionFosaprepitant dimeglumine 1 mg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0,7 mg/ml + injectionFosaprepitant dimeglumine 1 mg/ml + Sodium chloride 0,9%
injectionOndansetron hydrochloride Antiemetic
Compatible 0,07 mg/ml + injectionFosaprepitant dimeglumine 1 mg/ml + Sodium chloride 0,9%
injectionPalonosetron hydrochloride Antiemetic
Incompatible 2 µg/ml + injectionFosaprepitant dimeglumine 1 mg/ml
injectionTropisetron hydrochloride Antiemetic
Incompatible 0,043 mg/ml + injectionFosaprepitant dimeglumine 1 mg/ml + Sodium chloride 0,9%

  Mentions Légales