Last update :
08/11/2024
References   References 339  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/47/2/377

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Kleinberg ML, Duafala ME, Nacov C, Flora KP, Hines J, Davis K, McDaniel A, Scott D.
Title : Stability of heroin hydrochloride in infusion devices and containers for intravenous administration.
Reference : Am J Hosp Pharm ; 47: 377-381. 1990

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
injectionDiamorphine hydrochloride Analgesic
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 23°C-25°C Not specified
7 Day
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 23-25°C Not specified
12 Day
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 4°C Protect from light
15 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 20 mg/ml 23-25°C Not specified
15 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 20 mg/ml 4°C Protect from light
15 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 1 & 20 mg/ml 23-25°C Not specified
7 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 1 & 20 mg/ml 4°C Protect from light
15 Day

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