Last update :
19/11/2024
References   References 3366  
Type : Journal
Web link : http://onlinelibrary.wiley.com/doi/10.1002/jps.23403/abstract

Research teams : San Francisco - Genentech, Inc
Authors : Kwong Glover Z.W, Gennaro L, Yadav S, Demeule B, Wong P.Y, Sreedhara A.
Title : Compatibility and stability of pertuzumab and trastuzumab admixtures in i.v. infusion bags for coadministration.
Reference : J Pharm Sci ; DOI 10.1002 / jps.23403 2012

Level of Evidence : 
Level of evidence B+
Physical stability : 
Turbidimetry Protein: Size Exclusion Chromatography 
Chemical stability : 
Protein: ionic chromatography
Capillary electrophoresis
Protein: ultraviolet spectrometry
Other methods : 
Protein: ultracentrifugation 
Comments : 
Protein: no biological methods

List of drugs
injectionPertuzumab Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 3 mg/ml 30°C
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 3 mg/ml 5°C Not specified
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 3 mg/ml 30°C Light
24 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 3 mg/ml 5°C Not specified
24 Hour
Compatible 1,5 & 2,7 mg/ml + injectionTrastuzumab 1,5 & 2,3 mg/ml + Sodium chloride 0,9%
injectionTrastuzumab Anticancer drug
Compatible 1,5 & 2,3 mg/ml + injectionPertuzumab 1,5 & 2,7 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 30°C Light
injection Trastuzumab 2.3 mg/ml
injection Pertuzumab 2.7 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% 5°C Not specified
injection Trastuzumab 2.3 mg/ml
injection Pertuzumab 2.7 mg/ml
24 Hour
Polyolefine Sodium chloride 0,9% 30°C Protect from light
injection Trastuzumab 1.5 mg/ml
injection Pertuzumab 1.5 mg/ml
24 Hour
Polyolefine Sodium chloride 0,9% 30°C Light
injection Trastuzumab 2.3 mg/ml
injection Pertuzumab 2.7 mg/ml
24 Hour
Polyolefine Sodium chloride 0,9% 5°C Not specified
injection Trastuzumab 2.3 mg/ml
injection Pertuzumab 2.7 mg/ml
24 Hour

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