Last update :
14/12/2024
References   References 3327  
Type : Journal
Web link : http://www.ajhp.org/content/69/16/1405.abstract

Research teams : Kingston (USA) - University of Rhode Island, Department of Pharmacy Practice
Authors : LaPlante K.L, Woodmansee S, Mermel L.A.
Title : Compatibility and stability of telavancin and vancomycin in heparin or sodium citrate lock solutions.
Reference : Am J Health-Syst Pharm ; 69:1405-1409 2012

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
injectionHeparin sodium Anticoagulant
injectionSodium citrate Electrolyte
injectionTelavancin hydrochloride Antibiotic
injectionVancomycin hydrochloride Antibiotic
Stability of mixtures
Glass Sodium chloride 0,9% 37°C Protect from light
injection Telavancin hydrochloride 2 & 5 mg/ml
injection Heparin sodium 2500 UI/ml
injection Sodium citrate 22 & 40 mg/ml
72 Hour
Glass Sodium chloride 0,9% 37°C Protect from light
injection Vancomycin hydrochloride 2 & 5 mg/ml
injection Heparin sodium 2500 UI/ml
injection Sodium citrate 22 & 40 mg/ml
72 Hour

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