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References   References 3313  
Type : Journal
Web link : http://opp.sagepub.com/content/early/2011/11/09/1078155211426196.abstract?rss=1
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Kaiser J, Krämer I.
Title : Long-term stability study of clofarabine injection concentrate and diluted clofarabine infusion solutions.
Reference : J Oncol Pharm Practice ; 18, 2: 218-221. 2012
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionClofarabine Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,1 >> 0,3 mg/ml 2-8°C Protect from light
2 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,2 & 0,6 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,2 & 0,6 mg/ml 25°C With or without light
28 Day
  Mentions Légales