Last update :
08/11/2024
References   References 3306  
Type : Journal
Web link : http://www.esop.li/ejop.php

Research teams : Fribourg - University Hospital Freiburg, Department of Pharmacy
Authors : Trittler R.
Title : New stability studies for fludarabine according to the European Pharmacopoeia 7.0
Reference : EJOP ; 6, 1: 1-2. 2012

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
injectionFludarabine phosphate Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0,04 >> 1 mg/ml 2-8°C Protect from light
21 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 0,04 >> 1 mg/ml 25°C With or without light
21 Day

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