Last update :
08/11/2024
References   References 3189  
Type : Journal

Research teams : Heidelberg Vic - Austin Health, Pharmacy department
Authors : Tho T-P, Ching MS, Elis AG, Williams L, Garrett MK.
Title : Stability of intravenous flucloxacillin solutions used for hospital-in-the-home.
Reference : J Pharm Pract and Res ; 40, 2: 101-105. 2010

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Stability indicating capability inadequately assessed

List of drugs
injectionFlucloxacillin sodium Antibiotic
Factors which affect stability Temperature 37°C Induces Degradation
Factors which affect stability pH pH = 6.5 Induces Enhanced stability
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 120 mg/ml 2-8°C Not specified
6 Day
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 50 mg/ml 2-8°C Not specified
6 Day

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