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References   References 29  
Type : Journal
Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : Pinguet F, Rouanet P, Martel P, Fabbro M, Salabert D, Astre C.
Title : Compatibility and stability of granisetron, dexamethasone, and methylprednisolone in injectable solutions.
Reference : J Pharm Sci ; 84: 267-268. 1995
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.074 >> 1 mg/ml + injectionGranisetron hydrochloride 0.056 & 0.15 mg/ml + NaCl 0,9% or Glucose 5%
injectionGranisetron hydrochloride Antiemetic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,056 mg/ml -20°C Protect from light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,056 mg/ml 20°C Protect from light
3 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,056 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,15 mg/ml -20°C Protect from light
30 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,15 mg/ml 20°C Protect from light
3 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 0,15 mg/ml 4°C Protect from light
7 Day
Compatible 0.056 & 0.15 mg/ml + injectionDexamethasone sodium phosphate 0.074 >> 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.056 & 0.15 mg/ml + injectionMethylprednisolone sodium succinate 2.26 & 6 mg/ml + NaCl 0,9% or Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 2.26 & 6 mg/ml + injectionGranisetron hydrochloride 0.056 & 0.15 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 22°C Protect from light
injection Granisetron hydrochloride 0,056 mg/ml
injection Methylprednisolone sodium succinate 2,26 mg/ml
3 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 22°C Protect from light
injection Granisetron hydrochloride 0,056 mg/ml
injection Dexamethasone sodium phosphate 0.074 >> 0.345 mg/ml
3 Day
Polypropylen Syringe NaCl 0,9% or Glucose 5% 22°C Protect from light
injection Dexamethasone sodium phosphate 0,2 & 1 mg/ml
injection Granisetron hydrochloride 0,150 mg/ml
3 Day
Polypropylen Syringe NaCl 0,9% or Glucose 5% 22°C Protect from light
injection Granisetron hydrochloride 0,15 mg/ml
injection Methylprednisolone sodium succinate 6 mg/ml
3 Day
  Mentions Légales