Last update :
19/11/2024
References   References 2883  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/66/21/1929

Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : Eiden C, Philibert L, Bekhtari K, Poujol S, Malosse F, Fr?d?ric Pinguet F.
Title : Physicochemical stability of oxaliplatin in 5% dextrose injection stored in polyvinyl chloride, polyethylene, and polypropylene infusion bags.
Reference : Am J Health-Syst Pharm ; 66, 21: 1929-1933. 2009

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
injectionOxaliplatin Anticancer drug
Stability in solutions Polyvinyl chloride Glucose 5% 0,2 mg/ml 20°C With or without light
14 Day
Stability in solutions Polyvinyl chloride Glucose 5% 0,2 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1,3 mg/ml 20°C With or without light
14 Day
Stability in solutions Polyvinyl chloride Glucose 5% 1,3 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyethylene Glucose 5% 0,2 mg/ml 20°C With or without light
14 Day
Stability in solutions Polyethylene Glucose 5% 0,2 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polyethylene Glucose 5% 1,3 mg/ml 20°C With or without light
14 Day
Stability in solutions Polyethylene Glucose 5% 1,3 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polypropylene Glucose 5% 0,2 mg/ml 20°C With or without light
14 Day
Stability in solutions Polypropylene Glucose 5% 0,2 mg/ml 4°C Protect from light
14 Day
Stability in solutions Polypropylene Glucose 5% 1,3 mg/ml 20°C With or without light
14 Day
Stability in solutions Polypropylene Glucose 5% 1,3 mg/ml 4°C Protect from light
14 Day

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