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References   References 2881  
Type : Poster
Icone.pdf
390Ko
Research teams : Créteil - Henri Mondor University Hospital, Department of Pharmacy
Authors : Jaccoulet E, Guirao S, Morand K, Astier A, Paul M.
Title : Stabilité d'un anticorps monoclonal d'intérêt thérapeutique après reconstitution: le rituximab.
Reference : SFPO Congress 2009
Level of Evidence : 
Level of evidence B+
Physical stability : 
Turbidimetry Protein: Dynamic Light Scattering Protein: Size Exclusion Chromatography 
Chemical stability : 
Protein: Peptide mapping
Protein: ionic chromatography
Protein: ultraviolet spectrometry and second derivative
Other methods : 
Comments : 
Protein: no biological methods
List of drugs
injectionRituximab Anticancer drug
Factors which affect stability Temperature 40°C Induces Degradation
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml 4°C Protect from light
90 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 4 mg/ml 4°C Protect from light
90 Day
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