Last update :
08/11/2024
References   References 284  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/52/22/2560

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Xu QA, Martinez JF.
Title : Compatibility and stability of aztreonam and vancomycin hydrochloride.
Reference : Am J Health-Syst Pharm ; 52: 2560-2564. 1995

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
injectionAztreonam Antibiotic
Incompatible 40 mg/ml + injectionVancomycin hydrochloride 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionVancomycin hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Incompatible 10 mg/ml + injectionAztreonam 40 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionAztreonam 4 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 32°C Not specified
injection Aztreonam 4 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Aztreonam 4 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
31 Day
Polyvinyl chloride Sodium chloride 0,9% 23°C Not specified
injection Aztreonam 4 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
31 Day
Polyvinyl chloride Glucose 5% 23°C Not specified
injection Aztreonam 4 mg/ml
injection Vancomycin hydrochloride 1 mg/ml
14 Day

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