Last update :
25/08/2024
References   References 281  
Type : Journal

Research teams : Worcester - University of Massachusetts Medical Center, Department of pharmacy
Authors : Belliveau PP, Nightingale CH, Quintiliani R.
Title : Stability of cefotaxime sodium and metronidazole in 0.9% sodium chloride injection or in ready-to-use metronidazole bags.
Reference : Am J Health-Syst Pharm ; 52: 1561-1563. 1995

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
injectionCefotaxime sodium Antibiotic
Compatible 10 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionCefotaxime sodium 10 mg/ml + None
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 28°C Not specified
injection Cefotaxime sodium 10 mg/ml
injection Metronidazole 5 mg/ml
12 Hour
Polyvinyl chloride Sodium chloride 0,9% 5°C Protect from light
injection Cefotaxime sodium 10 mg/ml
injection Metronidazole 5 mg/ml
96 Hour

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