Last update :
08/11/2024
References   References 2683  
Type : Journal

Research teams : Birmingham - Dusley Road Hospital
Authors : Hebron B, Scott H.
Title : Shelf life of cefuroxime eye-drops when dispensed in artificial tear preparations.
Reference : Int J Pharm Pract ; 23: 163-167. 1993

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 

List of drugs
Eye-dropsCefuroxime sodium Antibiotic
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Distilled water >> 30 ml
25°C Protect from light
24 Hour
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
polyvinyl alcohol 1.4%
Hydroxyethylcellulose
Benzalkonium chloride 0.004%
Sodium edetate 0.02%
NaCl
NaOH
pH= 4.5-6
Distilled water >> 30 ml
25°C Protect from light
24 Hour
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Distilled water >> 30 ml
4°C Protect from light
14 Day
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
polyvinyl alcohol 1.4%
Hydroxyethylcellulose
Benzalkonium chloride 0.004%
Sodium edetate 0.02%
NaCl
NaOH
pH= 4.5-6
Distilled water >> 30 ml
4°C Protect from light
28 Day
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Hypromellose 0.25%
Chlorhexidine acetate 0.0075%
NaCl
Sodium bicarbonate
polysorbate 80
pH= 8-9
Distilled water >> 30 ml
25°C Protect from light
24 Hour
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Hypromellose 0.30%
NaCl
KCl
sodium borate
boric acid
pH= 8.45
Distilled water >> 30 ml
25°C Protect from light
24 Hour
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Hypromellose 0.25%
Chlorhexidine acetate 0.0075%
NaCl
Sodium bicarbonate
polysorbate 80
pH= 8-9
Distilled water >> 30 ml
4°C Protect from light
28 Day
Stability in solutions Glass Medicine bottle for injection 1500 mg
Zinacef®
Hypromellose 0.30%
NaCl
KCl
sodium borate
boric acid
pH= 8.45
Distilled water >> 30 ml
4°C Protect from light
28 Day

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