Last update :
19/11/2024
References   References 267  
Type : Journal

Research teams : Columbus - The Ohio State University Hospitals, Department of Pharmacy
Authors : Nahata MC, Edmonds JJ, Morosco RS.
Title : Stability of metronidazole and ceftizoxime sodium in ready-to-use metronidazole bags stored at 4 and 25°C.
Reference : Am J Health-Syst Pharm ; 53: 1046-1048. 1996

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionCeftizoxime sodium Antibiotic
Compatible 10 mg/ml + injectionMetronidazole 5 mg/ml + None
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionCeftizoxime sodium 10 mg/ml + None
Stability of mixtures
Polyvinyl chloride None 25°C Not specified
injection Metronidazole 5 mg/ml
injection Ceftizoxime sodium 10 mg/ml
3 Day
Polyvinyl chloride None 4°C Protect from light
injection Metronidazole 5 mg/ml
injection Ceftizoxime sodium 10 mg/ml
14 Day

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