Last update :
19/11/2024
References   References 262  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/50/4/703

Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Johnson CE, Jacobson PA, Pillen HA, Woycik CL.
Title : Stability and compatibility of fluconazole and aminophylline in intravenous admixtures.
Reference : Am J Hosp Pharm ; 50: 703-706. 1993

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Changes in pH not commented or difficult to interpret
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Degradation products not observed in real conditions

List of drugs
injectionAminophylline Various
Compatible 1 & 2 mg/ml + injectionFluconazole 0.5 & 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionFluconazole Antifungal
Compatible 0.5 & 1.5 mg/ml + injectionAminophylline 1 & 2 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 24°C Light
injection Fluconazole 0,5 & 1,5 mg/ml
injection Aminophylline 1 & 2 mg/ml
3 Hour

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