Last update :
08/11/2024
References   References 2420  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/55/13/1386

Research teams : Charleston - Medical University of South Carolina
Authors : Fuhrman LC, Jr, RT Stroman
Title : Stability of vancomycin in an extemporaneously compounded ophthalmic solution
Reference : Am J Health-Syst Pharm ; 55: 1386-1388 1998

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 

List of drugs
Eye-dropsVancomycin hydrochloride Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Not specified Medicine bottle for injection 465 mg
Vancocin®
hydroxypropylmethylcellulose 31.5 mg
Dextran 70 10.5 mg
Benzalkonium chloride 1.05 mg
Sodium edetate 5.25 mg
Water for injection >> 15 ml
-10°C Protect from light
45 Day
Stability in solutions Not specified Medicine bottle for injection 465 mg
Vancocin®
hydroxypropylmethylcellulose 31.5 mg
Dextran 70 10.5 mg
Benzalkonium chloride 1.05 mg
Sodium edetate 5.25 mg
Water for injection >> 15 ml
25°C
7 Day
Stability in solutions Not specified Medicine bottle for injection 465 mg
Vancocin®
hydroxypropylmethylcellulose 31.5 mg
Dextran 70 10.5 mg
Benzalkonium chloride 1.05 mg
Sodium edetate 5.25 mg
Water for injection >> 15 ml
4°C Protect from light
10 Day

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