Last update :
08/11/2024
References   References 2316  
Type : Journal
Web link : https://doi.org/10.1016/j.clinthera.2008.11.013

Research teams : Raritan - Johnson & Johnson Pharmaceutical Research & Development
Authors : Psathas P.A, Kuzmission A, Ikeda K, Yasuo S.
Title : Stability of doripenem in vitro in representative infusion solutions and infusion bags.
Reference : Clin Ther ; 30, 11: 2075-2087. 2008

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products quantified but not identified

List of drugs
injectionDoripenem Antibiotic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 25°C Light
12 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 5°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 5 mg/ml 25°C Light
4 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 5 mg/ml 5°C Protect from light
48 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 5 mg/ml 25°C Light
12 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 5 mg/ml 5°C Protect from light
72 Hour
Stability in solutions Polyethylene Glucose 5% 5 mg/ml 25°C Light
4 Hour
Stability in solutions Polyethylene Glucose 5% 5 mg/ml 5°C Protect from light
48 Hour

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